THIAMINE
(Vitamin B1)Standard Prescription
thiamine__mg PO{IM/IV}__(frequency)
Dosages
Patients at risk of Thiamine deficiency:
0.35-0.5mg/kg/day PO daily
Adult: 100 mg PO/IV/IM daily
*continue for 5-7 days, or longer if severe starvation, chronic alcoholism or other high risk of deficiency +/- signs of thiamine deficiency
Severe Deficiency, treatment:
Infant: 25-50 mg IV x 1 dose, then 10 mg IM daily x 1 week, then 3-5 mg PO daily x at least 6 weeks
Child: 10 mg IM/IV daily x 1 week (if critically ill), then 3-5 mg PO daily x at least 6 weeks
Adolescents: 100 mg IV/IM daily x up to 7 days (if critically ill), then 10 mg PO once daily
0.35-0.5mg/kg/day PO daily
Patients at risk of Refeeding Syndrome:
Child: 2 mg/kg PO/IV/IM daily. Max: 100-200 mg/dayAdult: 100 mg PO/IV/IM daily
*continue for 5-7 days, or longer if severe starvation, chronic alcoholism or other high risk of deficiency +/- signs of thiamine deficiency
Severe Deficiency, treatment:
Infant: 25-50 mg IV x 1 dose, then 10 mg IM daily x 1 week, then 3-5 mg PO daily x at least 6 weeks
Child: 10 mg IM/IV daily x 1 week (if critically ill), then 3-5 mg PO daily x at least 6 weeks
Adolescents: 100 mg IV/IM daily x up to 7 days (if critically ill), then 10 mg PO once daily
Mechanism of Action
Vitamin B1
Forms Supplied
tablet: 50 mg
liquid (BCCH): 100 mg/mL
injection: 100 mg/mL
liquid (BCCH): 100 mg/mL
injection: 100 mg/mL
Comments
Parenteral administration is preferred in critically ill patients.
Higher doses may be required in metabolic disorders such as Maple Syrup disease.
Start thiamine prior to initiating feeding or dextrose-containing IV fluid.
Higher doses may be required in metabolic disorders such as Maple Syrup disease.
Start thiamine prior to initiating feeding or dextrose-containing IV fluid.
References
44, 62, 259, 649
Last Edited
2022-09-12 00:27:06