IMIPENEM / CILASTATIN
(Primaxin)Standard Prescription
imipenem/cilastatin__mg IV Q H (__mg/kg/24hr)
Dosages
All doses are based on imipenem content
Children:
15 - 25 mg/kg/dose IV Q6H
Maximum: 1000 mg/dose
Adults:
500 - 1000 mg IV q6h
Maximum: 1000 mg/dose
Children:
15 - 25 mg/kg/dose IV Q6H
Maximum: 1000 mg/dose
Adults:
500 - 1000 mg IV q6h
Maximum: 1000 mg/dose
Mechanism of Action
Carbapenem antibiotic
Forms Supplied
injection: 500 mg imipenem and 500 mg cilastatin per vial
Comments
Not to be used for meningitis.
Cilastin blocks the metabolism of imipenem in the kidney.
Dose adjustment required in renal impairment.
Doses greater than 500 mg have a higher incidence of nausea/vomiting; slower infusion rates may decrease incidence of nausea/vomiting.
Seizures may occur, especially in those with underlying CNS disease, with overdose in patients with renal failure and with other predisposing factors.
Meropenem causes less nausea and vomiting and has a decreased risk of seizures compared to imipenem.
Cilastin blocks the metabolism of imipenem in the kidney.
Dose adjustment required in renal impairment.
Doses greater than 500 mg have a higher incidence of nausea/vomiting; slower infusion rates may decrease incidence of nausea/vomiting.
Seizures may occur, especially in those with underlying CNS disease, with overdose in patients with renal failure and with other predisposing factors.
Meropenem causes less nausea and vomiting and has a decreased risk of seizures compared to imipenem.
References
6, 44
Last Edited
2022-07-03 18:37:02