DRUG	SUPPLIED	DOSE	COMMENTS
IMIPENEM / CILASTATIN (Paeds) (Primaxin) Mechanism of action: Carbapenem antibiotic Ref: 6, 44 Last update: 2022-07-03	injection: 500 mg imipenem and 500 mg cilastatin per vial	All doses are based on imipenem content Children:   15 - 25 mg/kg/dose IV Q6H Maximum:   1000 mg/dose Adults: 500 - 1000 mg IV q6h Maximum:  1000 mg/dose	Not to be used for meningitis. Cilastin blocks the metabolism of imipenem in the kidney. Dose adjustment required in renal impairment. Doses greater than 500 mg have a higher incidence of nausea/vomiting; slower infusion rates may decrease incidence of nausea/vomiting. Seizures may occur, especially in those with underlying CNS disease, with overdose in patients with renal failure and with other predisposing factors. Meropenem causes less nausea and vomiting and has a decreased risk of seizures compared to imipenem. Standard Prescription: imipenem/cilastatin__mg IV Q   H (__mg/kg/24hr)