DOBUTAMINE
(Dobutrex)Standard Prescription
dobutamine__mcg/kg/min continuous IV infusion
Dosages
Hypotension
Infants, Children and Adults:
2-20 mcg/kg/min continuous IV infusion
Maximum Dose
40 mcg/kg/min (toxicity may occur)
Infants, Children and Adults:
2-20 mcg/kg/min continuous IV infusion
Maximum Dose
40 mcg/kg/min (toxicity may occur)
Mechanism of Action
Inotrope; Beta-1 adrenergic agonist with mild beta-2 effects (vasodilation); minimal effects on heart rate and peripheral vascular resistance
Forms Supplied
injection:
12.5 mg/mL 20 mL vial
(250 mg/20 mL vial)
pH = 2.5 - 5
Osmolality = 276
Contains EDTA & metabisulfite
Osmolality = 276
Contains EDTA & metabisulfite
Standard Concentrations for Critical Care:
2000 mcg/mL in D5W PFS
to make standard concentrations:
patients < 6 kg:
2000 mcg/mL
Add 4 mL of 12.5 mg/mL to 21 mL D5W to make 25 mL of 2000 mcg/mL
patients > 6 kg:
5000 mcg/mL
Add 10 mL of 12.5 mg/mL to 15 mL D5W to make 25 mL of 5000 mcg/mL
patients < 6 kg:
2000 mcg/mL
Add 4 mL of 12.5 mg/mL to 21 mL D5W to make 25 mL of 2000 mcg/mL
patients > 6 kg:
5000 mcg/mL
Add 10 mL of 12.5 mg/mL to 15 mL D5W to make 25 mL of 5000 mcg/mL
Use Alaris Pump to determine infusion rate.
AND
Confirm with the following calculation:
Infusion rate (mL/h) = Dose (mcg/kg/min) x Weight (kg) x 60 (min/h) divided by Concentration (mcg/mL)
AND
Confirm with the following calculation:
Infusion rate (mL/h) = Dose (mcg/kg/min) x Weight (kg) x 60 (min/h) divided by Concentration (mcg/mL)
Protect from light.
Change solution at 96 hours.
Pink discoloration of solution may occur - do not need to discard.
Change solution at 96 hours.
Pink discoloration of solution may occur - do not need to discard.
Comments
Central line administration preferred.
Peripheral line administration may be used for rates < 5 mcg/kg/min.
Rapid onset, short duration; T1/2 is 2 minutes.
Correct hypovolemia before use.
Tachycardia, dysrhythmias and hypertension may occur with larger doses.
Contains sulfite: may cause allergic reaction in susceptible individuals.
Extravasation may cause tissue necrosis.
For treatment of extravasation see phentolamine protocol on ePOPS.
Peripheral line administration may be used for rates < 5 mcg/kg/min.
Rapid onset, short duration; T1/2 is 2 minutes.
Correct hypovolemia before use.
Tachycardia, dysrhythmias and hypertension may occur with larger doses.
Contains sulfite: may cause allergic reaction in susceptible individuals.
Extravasation may cause tissue necrosis.
For treatment of extravasation see phentolamine protocol on ePOPS.
References
37, 44, 141
Last Edited
2019-01-24 06:41:38