DRUG | SUPPLIED | DOSE | COMMENTS |
---|---|---|---|
DOBUTAMINE (Paeds) (Dobutrex) Mechanism of action: Inotrope; Beta-1 adrenergic agonist with mild beta-2 effects (vasodilation); minimal effects on heart rate and peripheral vascular resistance Ref: 37, 44, 141 Last update: 2019-01-24 |
injection: 12.5 mg/mL 20 mL vial (250 mg/20 mL vial) pH = 2.5 - 5 Osmolality = 276 Contains EDTA & metabisulfite Standard Concentrations for Critical Care: 2000 mcg/mL in D5W PFS to make standard concentrations: patients < 6 kg: 2000 mcg/mL Add 4 mL of 12.5 mg/mL to 21 mL D5W to make 25 mL of 2000 mcg/mL patients > 6 kg: 5000 mcg/mL Add 10 mL of 12.5 mg/mL to 15 mL D5W to make 25 mL of 5000 mcg/mL Use Alaris Pump to determine infusion rate. AND Confirm with the following calculation: Infusion rate (mL/h) = Dose (mcg/kg/min) x Weight (kg) x 60 (min/h) divided by Concentration (mcg/mL) Protect from light. Change solution at 96 hours. Pink discoloration of solution may occur - do not need to discard. |
Hypotension Infants, Children and Adults: 2-20 mcg/kg/min continuous IV infusion Maximum Dose 40 mcg/kg/min (toxicity may occur) |
Central line administration preferred. Peripheral line administration may be used for rates < 5 mcg/kg/min. Rapid onset, short duration; T1/2 is 2 minutes. Correct hypovolemia before use. Tachycardia, dysrhythmias and hypertension may occur with larger doses. Contains sulfite: may cause allergic reaction in susceptible individuals. Extravasation may cause tissue necrosis. For treatment of extravasation see phentolamine protocol on ePOPS. Standard Prescription: dobutamine__mcg/kg/min continuous IV infusion |