MEDICATION DOSAGES & INTERVALS OF ADMINISTRATION ROUTE & FINAL DILUTION DILUTION INSTRUCTIONS STABILITY RATE OF INFUSION & COMMENTS
MILRINONE LACTATE (Neo)
 (Primacor)

Mechanism of action:

Myocardial phosphodiesterase inhibitor with inotropic, lusitropic and vasodilator (decreased afterload) effects.


1 mg/mL injection



Ref: 14, 178 - 181



Last update: 2025-09-11
Treatment of low cardiac output states, post-cardiac surgery, pulmonary hypertension:

Maintenance Infusion:
0.25 - 0.75 mcg/kg/min IV infusion. Titrate to effect

 IV

Standard Concentrations:

100 mcg/mL in D5W in 3 mL and 25 mL Syringes

200 mcg/ml in D5W in 25 mL syringes

400 mcg/ml in D5W in 25 mL  syringes

 100 mcg/mL x 3 mL syringe:
Add 0.3 mL of milrinone 1 mg/mL to 2.7 mL of D5W to make 3 mL of 100 mcg/mL

100 mcg/mL x 25 mL syringe:
Add 2.5 mL of milrinone 1 mg/mL to 22.5 mL of D5W to make 25 mL of 100 mcg/mL

200 mcg/mL x 25 mL syringe:
Add 5 mL of milrinone 1 mg/mL to 20 mL of D5W to make 25 mL of 200 mcg/mL

400 mcg/mL x 25 mL syringe:
Add 10 mL of milrinone 1 mg/mL to 15 mL of D5W to make 25 mL of 400 mcg/mL

 4 days room temperature
 Administration:
**Continuous Critical Infusion**
1.     Do not interrupt.
2.     Never bolus solutions/medications into same lumen.
3.     Use pressure sensing disc tubing.


COMMENTS:
**Continuous Critical Infusion**
1.     Do not interrupt.
2.     Never bolus solutions/medications into same lumen.
3.     Use pressure sensing disc tubing.

All orders must be approved by the attending Neonatologist.

Primarily eliminated unchanged via kidneys. Reduction of dosage may be required in prematurity and patients with renal impairment.

Monitor: 
Blood pressure, heart rate, ECG, electrolytes, fluid balance, renal function, platelets.



Standard Prescription:

milrinone__mcg IV x 1 loading dose (__mcg/kg).

milrinone __mcg/kg/min continuous IV infusion.