CEFUROXIME
(Ceftin = cefuroxime axetil [po], Zinacef)Standard Prescription
cefuroxime __mg IV/IM Q H (__mg/kg/24h)
cefuroxime __mg PO BID (__mg/kg/24h)
cefuroxime __mg PO BID (__mg/kg/24h)
Dosages
Children:
Osteomyelitis:
Adults:
Oral dosing:
Adults:
250-500 mg/dose PO BID
25-50 mg/kg/dose IV Q8H. Max. 2000 mg/dose
50 mg/kg/dose IV Q8H. Max 1500 mg/dose
750-1500 mg/dose IV Q8H
Children: 10-15 mg/kg/dose PO BID. Max. 500 mg/dose
Osteomyelitis:
33 mg/kg/dose PO TID. Max. 1000 mg/dose
250-500 mg/dose PO BID
Mechanism of Action
Second generation cephalosporin antibiotic
Forms Supplied
injection: 750 mg, 1.5 g
tablets: 250 mg, 500 mg
tablets: 250 mg, 500 mg
Comments
Bioavailability of the oral tablet is increased when administered with food.
Cefuroxime axetil oral suspension is not palatable and is less bioavailable than the tablet; see cefprozil for second generation oral cephalosporin.
Dosage adjustment required in renal impairment.
Cefuroxime axetil oral suspension is not palatable and is less bioavailable than the tablet; see cefprozil for second generation oral cephalosporin.
Dosage adjustment required in renal impairment.
References
6, 44, 227, 614
Last Edited
2022-06-16 00:21:18