MIRTAZAPINE
(Remeron, Remeron RD)Standard Prescription
Mirtazapine __ mg PO HS
Dosages
Adolescents/Adults:
Initial: 7.5-15 mg PO HS.
May increase in 15 mg increments at weekly or greater intervals to maximum dose of 45 mg PO HS.
Mechanism of Action
Norepinephrine agonist/specific serotonin antagonist (NaSSA) antidepressant (not a firstline choice)
Forms Supplied
tablet: 15 mg, 30 mg, 45 mg
oral disintegrating tablet: (not stocked at BCCH) 15 mg, 30 mg, 45 mg
Comments
A norepinephrine agonist/specific serotonin antagonist (NaSSA) antidepressant (not a firstline choice)
Prescribers must be aware of warnings issued by Health Canada regarding the use of antidepressants in pediatric patients. Refer to the Health Canada website.
Adverse effects include: increased appetite, weight gain, drowsiness/sedation, dry mouth, dizziness, weakness, increased ALT, rare QTc prolongation.
Sedation effects are paradoxically stronger at lower doses and less strong at higher doses.
Prescribers must be aware of warnings issued by Health Canada regarding the use of antidepressants in pediatric patients. Refer to the Health Canada website.
References
4, 44, 83
Last Edited
2021-08-02 02:42:49