ANAKINRA

 (Kineret)

Standard Prescription

__ mg/kg/dose SC once daily

Dosages

Rheumatic diseases: eg. systemic onset juvenile idiopathic arthritis, periodic fever syndromes.

1-2 mg/kg/dose SC once daily (Max 100 mg/dose).

If no response, may double dose at 2 week intervals to a max of 4 mg/kg/dose (Max 200 mg/dose).

Mechanism of Action

Anakinra blocks the biologic activity of IL-1 by competitively inhibiting IL-1 binding to the interleukin-1 type I receptor (IL-1RI)

Forms Supplied

Injection: 100 mg PFS

Comments

Adverse effects include injection site irritation, headache, diarrhea, nausea, vomiting, fever and infection.

Risk of infection: do not use in patients with severe infection. All patients should be evaluated for both acute and latent tuberculosis before starting treatment.

Administration of live vaccinations to patients on anakinra not recommended.

References

44, 325, 326

Last Edited

2021-06-22 03:38:36