SOTALOL
(Sotacor)Standard Prescription
sotalol__mg PO Q__H (__mg/kg/24hour)
Dosages
< 2 yr : 30 mg/m2/dose x age related factor PO Q8H
refer to nomogram for age related factor (see link in comments)
>2 yr Initial: 0.7- 1 mg/kg/dose PO Q8H or Q12H
Usual starting dose: 1 mg/kg/dose PO Q12H
Increment: 1-2 mg/kg/24 hr every 3 days
Maximum: 2.7 mg/kg/dose PO Q8H (8 mg/kg/24 hours)
OR
Initial: 30 mg/m2/dose PO Q8H
Max: 60 mg/m2/dose PO Q8H
Adults: 80 mg PO BID to max 320 mg/24hr
refer to nomogram for age related factor (see link in comments)
Cardiology Consult required
Usual starting dose: 1 mg/kg/dose PO Q12H
Increment: 1-2 mg/kg/24 hr every 3 days
Maximum: 2.7 mg/kg/dose PO Q8H (8 mg/kg/24 hours)
OR
Initial: 30 mg/m2/dose PO Q8H
Max: 60 mg/m2/dose PO Q8H
Adults: 80 mg PO BID to max 320 mg/24hr
Mechanism of Action
Class III antiarrhythmic agent (prolongs action potential) with minor class II (non-selective beta-blocking) effects.
Forms Supplied
Tablet: 80 mg, 160 mg
Suspension (BCCH): 5 mg/mL
Suspension (BCCH): 5 mg/mL
Comments
Class III antiarrhythmic agent (prolongs action potential) with minor class II (non-selective beta-blocking) effects
Reduce dose in renal impairment.
Use caution in reactive airway disease.
May cause pro-arrhythmic effects e.g. prolongation of QT and risk of torsade, AV block.
Dosing for < 2 years old found on UpToDate at: http://www.uptodate.com/contents/images/DRUG/78350/Sotalol.jpg?title=Age+nomogram.
Reduce dose in renal impairment.
Use caution in reactive airway disease.
May cause pro-arrhythmic effects e.g. prolongation of QT and risk of torsade, AV block.
Dosing for < 2 years old found on UpToDate at: http://www.uptodate.com/contents/images/DRUG/78350/Sotalol.jpg?title=Age+nomogram.
References
44, 52, 242
Last Edited
2022-09-11 02:41:17