SULFASALAZINE
(Salazopyrin, Salazopyrin-EN)Standard Prescription
sulfasalazine__mg PO Q__H
Dosages
20-35 mg/kg/dose PO BID (Max 4 g/day)
Mechanism of Action
Prodrug of 5-aminosalicylic acid (5-ASA) linked to sulfapyridine; 5-ASA compounds have anti-inflammatory and immunosuppressive properties.
Forms Supplied
tablet: 500 mg
enteric coated tablet: 500 mg
BCCH suspension: 50mg/mL
enteric coated tablet: 500 mg
BCCH suspension: 50mg/mL
Comments
Patients experiencing GI side effects with the uncoated tablets should use the enteric coated tablets, a lower dose, or a different 5-ASA preparation.
Contraindicated in patients with sulfa or salicylate allergy and severe renal or hepatic impairment.
Once daily dosing is equally effective but may result in more side effects.
Maintenance doses should be similar. Lower doses may be considered after a period of sustained remission. The minimum effective dose in adults is 1.2 g/day.
May interact with cyclosporine (decreased cyclosporine levels).
Contraindicated in patients with sulfa or salicylate allergy and severe renal or hepatic impairment.
Once daily dosing is equally effective but may result in more side effects.
Maintenance doses should be similar. Lower doses may be considered after a period of sustained remission. The minimum effective dose in adults is 1.2 g/day.
May interact with cyclosporine (decreased cyclosporine levels).
References
4, 320, 429
Last Edited
2019-08-26 11:21:08