TOBRAMYCIN
Standard Prescription
tobramycin__mg IM/IV Q__H (__mg/kg/24hr)
Dosages
Children:
Traditional:
2.5 mg/kg/dose IM/IV Q8H.
Extended interval :
7 mg/kg/dose IV once daily
Cystic Fibrosis:
4 mg/kg/dose IV Q8H. May be increased based on serum levels.
Adults: 1-2.5 mg/kg/dose Q8H
Traditional:
2.5 mg/kg/dose IM/IV Q8H.
Extended interval :
7 mg/kg/dose IV once daily
Cystic Fibrosis:
4 mg/kg/dose IV Q8H. May be increased based on serum levels.
Adults: 1-2.5 mg/kg/dose Q8H
Mechanism of Action
Aminoglycoside antibiotic
Forms Supplied
injection: 10 mg/mL, 40 mg/mL
Comments
Extended interval dosing should NOT be used in patients with renal dysfunction (GFR <90), CF patients, endocarditis, surgical prophylaxis, burns >20% of body or in Gram positive infections where aminoglycoside is being used with another antibiotic for synergy.
Adjust dose in renal impairment.
For extended interval dosing obtain baseline creatinine; for therapy beyond 7 days check creatinine at least twice weekly.
Administer extended interval and traditional interval doses over 30 min.
Dose may be adjusted based on serum concentrations.
Therapeutic serum concentrations:
Traditional dosing:
Trough (pre-dose) < 2 mg/L
Peak (post-dose) 6-10 mg/L (10-15 mg/L in CF)
Extended interval dosing:
Trough (Pre-dose) < 1 mg/mL
No post-dose level is required
Refer to Therapeutic Drug Monitoring Table in References and Supplementary (white pages in print copy)
Adjust dose in renal impairment.
For extended interval dosing obtain baseline creatinine; for therapy beyond 7 days check creatinine at least twice weekly.
Administer extended interval and traditional interval doses over 30 min.
Dose may be adjusted based on serum concentrations.
Therapeutic serum concentrations:
Traditional dosing:
Trough (pre-dose) < 2 mg/L
Peak (post-dose) 6-10 mg/L (10-15 mg/L in CF)
Extended interval dosing:
Trough (Pre-dose) < 1 mg/mL
No post-dose level is required
Refer to Therapeutic Drug Monitoring Table in References and Supplementary (white pages in print copy)
References
6, 44, 630
Last Edited
2022-09-12 00:32:24