OXCARBAZEPINE
(Trileptal)Standard Prescription
oxcarbazepine__mg PO Q__H (__mg/kg/24hr)
Dosages
Children > 2 years old:
Initial: 4-5 mg/kg/dose PO BID (Max: 300 mg/dose).
Increment: 2.5 mg/kg/dose PO BID every 3-7 days.
Adolescents:
Switching from carbamazepine to oxcarbazepine:
oxcarbazepine dose = 1.5 x carbamazepine dose.
Initial: 4-5 mg/kg/dose PO BID (Max: 300 mg/dose).
Increment: 2.5 mg/kg/dose PO BID every 3-7 days.
Maintenance: 15-25 mg/kg/dose PO BID.
Maximum:
< 4 years old: 30 mg/kg/dose PO BID.
> 4 years old: 1050 mg/dose PO BID.
Adolescents:
Initial: 300 mg/dose PO BID.
Increment: 150 mg/dose PO BID every 3 to 7 days.
Maintenance: 600-750mg/dose PO BID.
Maximum: 1200 mg/dose PO BID.
Switching from carbamazepine to oxcarbazepine:
oxcarbazepine dose = 1.5 x carbamazepine dose.
Mechanism of Action
Anticonvulsant; fast sodium channel blocker
Forms Supplied
tablet: 150 mg, 300 mg, 600 mg
suspension: 60 mg/mL
suspension: 60 mg/mL
Comments
Structurally related to carbamazepine and believed to cause less frequent, severe side effects; however hyponatremia is more common than with carbamazepine.
25-35% incidence of cross-sensitivity with carbamazepine.
Risk of Stevens Johnson Syndrome.
Drug interactions: Inhibits CYP2C19 and induces CYP3A4.
25-35% incidence of cross-sensitivity with carbamazepine.
Risk of Stevens Johnson Syndrome.
Drug interactions: Inhibits CYP2C19 and induces CYP3A4.
References
44, 112, 365
Last Edited
2019-08-09 17:22:02