LORAZEPAM
(Ativan)Standard Prescription
lorazepam__mg PO/SL/IV q__h (__mg/kg/dose) (prn)
lorazepam__mg PO/SL/IV x 1 dose (__mg/kg/dose)
lorazepam__mg PO/SL/IV x 1 dose (__mg/kg/dose)
Dosages
Anxiolytic:
0.05 mg/kg/dose PO/SL/IV/IM Q4-8H.
Maximum : 2 mg/dose
Pre-Procedure Sedation:
0.05 mg/kg/dose SL/IM 2 hr before procedure.
Maximum: 4 mg/dose.
Status Epilepticus:
0.1 mg/kg/dose IV/IO. (Max: 4 mg/dose)
May repeat in 5 - 10 min.
Seizure Rescue:
0.1 mg/kg/dose SL (Max: 4 mg/dose).
May repeat in 10 min.
0.05 mg/kg/dose PO/SL/IV/IM Q4-8H.
Maximum : 2 mg/dose
Pre-Procedure Sedation:
0.05 mg/kg/dose SL/IM 2 hr before procedure.
Maximum: 4 mg/dose.
Status Epilepticus:
0.1 mg/kg/dose IV/IO. (Max: 4 mg/dose)
May repeat in 5 - 10 min.
Seizure Rescue:
0.1 mg/kg/dose SL (Max: 4 mg/dose).
May repeat in 10 min.
Mechanism of Action
Benzodiazepine
Forms Supplied
sublingual tablet: 0.5 mg, 1 mg, 2 mg
suspension (BCCH): 0.4 mg/mL
injection: 4 mg/mL (1 mL)Standard concentrations for Critical Care:
PICU: 0.2 mg/mL
Comments
Sublingual tablets can be given orally.
IV administration rate not to exceed 2 mg/min.
For anxiety, benzodiazepines are for symptomatic treatment only, and alternative strategies to replace benzodiazepine use should be sought quickly.
Doses higher than those used as an anxiolytic may be required for treatment of catatonia consult specialist.
Does not undergo oxidative metabolism.
Dosage adjustment not required for patients with impaired hepatic function.
IV administration rate not to exceed 2 mg/min.
For anxiety, benzodiazepines are for symptomatic treatment only, and alternative strategies to replace benzodiazepine use should be sought quickly.
Doses higher than those used as an anxiolytic may be required for treatment of catatonia consult specialist.
Does not undergo oxidative metabolism.
Dosage adjustment not required for patients with impaired hepatic function.
Benzodiazepines are habit-forming, commonly abused, and have a significant street value.
Midazolam is the preferred agent for rescue of prolonged seizures if using non-IV route.
References
4, 44, 83, 336, 557
Last Edited
2022-07-05 19:36:43