HYDROXYUREA
(Hydrea)Standard Prescription
HYDROXYUREA __mg PO daily/BID/TID (__mg/kg/24hr)
Dosages
Sickle cell anemia:
Initial: 20 mg/kg/dose PO daily. Increase by 5 mg/kg/dose every 8 weeks as needed
Maximum 35 mg/kg/dose PO daily
Hyperleukocytosis during treatment of acute promyelocytic leukemia:
30 mg/kg/dose PO QID. Max 1000 mg/dose
Hyperleukocytosis secondary to chronic myeloid leukemia:
20-25 mg/kg/dose PO TID-QID. Max 6000 mg/day
Initial: 20 mg/kg/dose PO daily. Increase by 5 mg/kg/dose every 8 weeks as needed
Maximum 35 mg/kg/dose PO daily
Hyperleukocytosis during treatment of acute promyelocytic leukemia:
30 mg/kg/dose PO QID. Max 1000 mg/dose
Hyperleukocytosis secondary to chronic myeloid leukemia:
20-25 mg/kg/dose PO TID-QID. Max 6000 mg/day
Mechanism of Action
Forms Supplied
Capsules: 500 mg
Oral Suspension (BCCH): 100 mg/mL
Oral Suspension (BCCH): 100 mg/mL
Comments
Monitor white blood cell count and adjust dose accordingly.
For sickle cell anemia, may take 3-6 months for clinical response.
For sickle cell anemia, may take 3-6 months for clinical response.
References
44, 548, 549, 550
Last Edited
2022-07-03 03:01:13