HYALURONIDASE
Standard Prescription
hyaluronidase 150 units/mL in NS: inject sc/intradermally around extravasation site per protocol
Dosages
Tissue Injury secondary to Extravasation:
(by physician only)
Draw up 0.2 mL of 150 Unit/mL into 4 or 5 one mL syringes. Inject 0.1-0.2 mL (15-30 units) subcutaneously or intradermally in 4 to 5 sites around the circumference of infiltrate, using a new needle with each injection.
Wait 10 to 15 minutes and inject 3 to 5 mL NS into each injection site.
Do not administer intravenously.
Mechanism of Action
Extravasation antidote; proteolytic enzyme
Forms Supplied
Injection: 150 units/mL
Available through Health Canada Special Access Program. A supply is kept in the pharmacy and may be used for any patient in the hospital (pharmacy is to track usage).
Available through Health Canada Special Access Program. A supply is kept in the pharmacy and may be used for any patient in the hospital (pharmacy is to track usage).
Comments
Refer to Prevention and Management of Infiltration and Extravasation Policy and Guidelines for Antidote Administration on PHSA SHOP for a complete listing of agents for which hyaluronidase treatment may be useful and for further information on management of extravasation.
Most benefit if injected within 1 hour of extravasation.
References
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Last Edited
2023-04-16 00:49:31