ETHOSUXIMIDE
(Zarontin)Standard Prescription
ethosuximide__mg PO Q__H (__mg/kg/24hr)
Dosages
Children 3-6 years old:
Initial: 2.5-5 mg/kg/dose PO BID (Max: 250 mg/dose)
Increment: 1.25-2.5 mg/kg/dose PO BID every 5-7 days
Maintenance: 7.5-20 mg/kg/dose PO BID
Maximum: 750 mg/dose PO BID
Children > 6 years old:
Initial: 250 mg/dose PO daily to BID
Increment: 250 mg/dose PO daily every 5-7 days
Maintenance: 10-20 mg/kg/dose PO BID
Maximum: 750 mg/dose PO BID
Initial: 2.5-5 mg/kg/dose PO BID (Max: 250 mg/dose)
Increment: 1.25-2.5 mg/kg/dose PO BID every 5-7 days
Maintenance: 7.5-20 mg/kg/dose PO BID
Maximum: 750 mg/dose PO BID
Children > 6 years old:
Initial: 250 mg/dose PO daily to BID
Increment: 250 mg/dose PO daily every 5-7 days
Maintenance: 10-20 mg/kg/dose PO BID
Maximum: 750 mg/dose PO BID
Mechanism of Action
Anticonvulsant. It blocks of T-type calcium channels, and may include effects on other classes of ion channel.
Forms Supplied
capsule: 250 mg
syrup: 50 mg/mL
syrup: 50 mg/mL
Comments
Adverse Effects: include GI disturbance if taken on an empty stomach, sedation, rarely allergic reactions including Stevens Johnson syndrome; rarely causes psychosis (mostly in teenagers).
References
32, 44, 557
Last Edited
2022-06-24 04:27:43