DICLOFENAC
(Voltaren, Voltaren Ophta)Standard Prescription
diclofenac suppository__mg PR Q__H (__mg/kg/dose)
diclofenac eye drops: Instill__drop(s) to __eye(s)__(frequency)
diclofenac eye drops: Instill__drop(s) to __eye(s)__(frequency)
Dosages
Children:
Rectal: 0.5 - 1 mg/kg/dose (round to nearest 12.5 mg) PR Q812H (Max: 50 mg/dose)
Maximum: 100 mg/24 hours
Adults:
Ophthalmic: one drop 4 times daily (44)
Rectal: 0.5 - 1 mg/kg/dose (round to nearest 12.5 mg) PR Q812H (Max: 50 mg/dose)
Maximum: 100 mg/24 hours
Adults:
Ophthalmic: one drop 4 times daily (44)
Mechanism of Action
Non-steroidal anti-inflammatory drug (NSAID)
Forms Supplied
suppository: 12.5 mg, 25 mg (made locally for BCCH) & 50 mg (commercially available)
eye drops: 0.1% multidose bottle (5mL)
eye drops: 0.1% multidose bottle (5mL)
Comments
May increase serum levels of digoxin, methotrexate and lithium. May decrease the antiplatelet effects of ASA.
Note: concomitant use of methotrexate and NSAID is a standard of care for treating JIA
If suppositories are to be split in half, the splitting should be done lengthwise.
Note: concomitant use of methotrexate and NSAID is a standard of care for treating JIA
If suppositories are to be split in half, the splitting should be done lengthwise.
References
44, 107, 159, 506, 507
Hashkes PJ, Laxer RM. Medical treatment of juvenile idiopathic arthritis. JAMA. 2005;294(13):1671-1684.
Petty RE, Laxer RM, Lindsley CB, Wedderburn LR. Textbook of Pediatric Rheumatology. 7th ed. Elsevier; 2016.
Petty RE, Laxer RM, Lindsley CB, Wedderburn LR. Textbook of Pediatric Rheumatology. 7th ed. Elsevier; 2016.
Last Edited
2021-08-01 22:36:05