| MEDICATION | DOSAGES & INTERVALS OF ADMINISTRATION | ROUTE & FINAL DILUTION | DILUTION INSTRUCTIONS | STABILITY | RATE OF INFUSION & COMMENTS |
|---|---|---|---|---|---|
| ZIDOVUDINE (ZDV, AZT) (Neo) (Retrovir) Mechanism of action: Nucleoside reverse transcriptase inhibitor (NRTI). Converted intracellularly to active triphosphate metabolite which inhibits HIV reverse transcriptase by viral DNA chain termination. 10 mg/mL injection 10 mg/mL oral syrup Ref: 244, 245 Last update: 2023-09-13 |
Prevention of Perinatal HIV Transmission Birthing Individual/Mother known to be HIV Positive Low Risk (Duration = 4 weeks) GA >=35 weeks: 4 mg/kg/dose PO Q12H x 4 weeks OR 3 mg/kg/dose IV Q12H x 4 weeks GA 30 - 34 weeks: 2 mg/kg/dose PO Q12H x 2 weeks then 3 mg/kg/dose PO Q12H x 2 weeks OR 1.5 mg/kg/dose IV Q12H x 2 weeks then 2.3 mg/kg/dose IV Q12H x 2 weeks GA <=29 weeks: 2 mg/kg/dose PO Q12H x 4 weeks OR 1.5 mg/kg/dose IV Q12H x 4 weeks Moderate or High Risk or Birthing Individual/Mother with HIV Infection Not Ruled Out (Duration = 6 weeks) GA >=35 weeks GA: 4 mg/kg/dose PO Q12H x 6 weeks OR 3 mg/kg/dose IV Q12H x 6 weeks GA 30 - 34 weeks: 2 mg/kg/dose PO Q12H x 2 weeks then 3 mg/kg/dose PO Q12H x 4 weeks OR 1.5 mg/kg/dose IV Q12H x 2 weeks then 2.3 mg/kg/dose IV Q12H x 4 weeks GA <=29 weeks GA 2 mg/kg/dose PO Q12H x 4 weeks then 3 mg/kg/dose PO Q12H x 2 weeks OR 1.5 mg/kg/dose IV Q12H x 4 weeks then 2.3 mg/kg/dose IV Q12H x 2 weeks Presumptive Therapy If Birthing Individual/Mother is known to be HIV positive and very high risk (HIV VL > 1000 copies/mL) contact Oak Tree Clinic for dosing |
PO: 10 mg/mL |
IV: Mix 1 mL of 10 mg/mL concentration with 9 mL of D5W or NS in a 10 mL empty sterile vial = 1 mg/mL. |
10 mg/mL: Discard unused portion 1 mg/mL: 24 hour (refrigerate) or 8 hours (room temperature) Oral syrup is stored at room temperature |
Administration: Infuse over 60 minutes. COMMENTS: Obtain medications from the Prevention of Perinatal HIV Transmission kits. Call Oak Tree at 604-875-2250 to inform them of delivery and consultation for monitoring therapy. Click here for Oak Tree Clinic Guidelines. For infants of Birthing Individual/Mother at high risk of HIV, infant medications may be discontinued if maternal HIV infection ruled out (based on maternal HIV diagnostic PCR) in consultation with Oak Tree Clinic. If infant discharged on zidovudine send supply home with caregiver. Oral route preferred. Oral dose can be administered with feeds or on an empty stomach. Do not mix zidovudine into formula. For treatment dosing of children living with HIV please contact the Oak Tree Clinic. Standard Prescription: zidovudine__mg {PO} {IV} Q__H |